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Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy

Abstract:
Objective To determine whether blood biomarkers of neuronal damage (neurofilament light chain [NfL]), muscle damage (creatine kinase [CK]), and muscle mass (creatinine) are altered in spinal and bulbar muscular atrophy (SBMA) and can be used as biomarkers for disease severity.

Methods In this multicenter longitudinal prospective study, plasma and serum were collected from 2 cohorts of patients with SBMA in London, United Kingdom (n = 50), and Padov... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1212/wnl.0000000000007097

Authors


Lombardi, V More by this author
Zampedri, L More by this author
Martinelli, I More by this author
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Grant:
Fratta/Jan15/946-795
MALASPINA/APR13/817-791
Wellcome Trust More from this funder
Publisher:
American Academy of Neurology Publisher's website
Journal:
Neurology Journal website
Volume:
92
Issue:
11
Publication date:
2019-02-20
Acceptance date:
2018-11-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
Pubs id:
pubs:980881
URN:
uri:4bb2796a-3ef8-4535-8617-677bd3755559
UUID:
uuid:4bb2796a-3ef8-4535-8617-677bd3755559
Local pid:
pubs:980881
Language:
English

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