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Possible role of differential growth in airway wall remodeling in asthma.

Abstract:

Airway remodeling in patients with chronic asthma is characterized by a thickening of the airway walls. It has been demonstrated in previous theoretical models that this change in thickness can have an important mechanical effect on the properties of the wall, in particular on the phenomenon of mucosal folding induced by smooth muscle contraction. In this paper, we present a model for mucosal folding of the airway in the context of growth. The airway is modeled as a bilayered cylindrical tube...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of applied physiology (Bethesda, Md. : 1985)
Volume:
110
Issue:
4
Pages:
1003-1012
Publication date:
2011-04-05
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
URN:
uuid:4bb01af1-4995-4a44-9e25-a9c36ad4a989
Source identifiers:
188760
Local pid:
pubs:188760

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