- Abstract:
-
We have monitored whole-cell and single channel ATP-sensitive K+ (KATP) currents in isolated rat glucagon-secreting pancreatic A-cells. Tolbutamide produced a concentration-dependent decrease in the whole-cell KATP conductance (Ki = 6 microM) and initiated action potential firing. The K+ channel opener diazoxide, but not cromakalim or pinacidil, inhibited electrical activity and increased the whole-cell K+ conductance fourfold. ATP applied to the intracellular face of the membrane inhibited K...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s004240051058
-
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- Journal:
- Pflugers Archiv : European journal of physiology
- Volume:
- 438
- Issue:
- 4
- Pages:
- 428-436
- Publication date:
- 1999-09-05
- DOI:
- EISSN:
-
1432-2013
- ISSN:
-
0031-6768
- URN:
-
uuid:4b9740f1-85fa-4f09-b227-20bc78d4facb
- Source identifiers:
-
10485
- Local pid:
- pubs:10485
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
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