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Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.

Abstract:

We have monitored whole-cell and single channel ATP-sensitive K+ (KATP) currents in isolated rat glucagon-secreting pancreatic A-cells. Tolbutamide produced a concentration-dependent decrease in the whole-cell KATP conductance (Ki = 6 microM) and initiated action potential firing. The K+ channel opener diazoxide, but not cromakalim or pinacidil, inhibited electrical activity and increased the whole-cell K+ conductance fourfold. ATP applied to the intracellular face of the membrane inhibited K...

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Publication status:
Published

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Publisher copy:
10.1007/s004240051058

Authors


Bokvist, K More by this author
Gotfredsen, CF More by this author
Holmes, WF More by this author
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Journal:
Pflugers Archiv : European journal of physiology
Volume:
438
Issue:
4
Pages:
428-436
Publication date:
1999-09-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:4b9740f1-85fa-4f09-b227-20bc78d4facb
Source identifiers:
10485
Local pid:
pubs:10485

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