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Genomic epidemiology of artemisinin resistant malaria.

Abstract:

The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.08714

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Funding agency for:
Kwiatkowski, D
Ashley, E
Day, N
Dondorp, A
Woodrow, C
Sinha, I
White, N
Miotto, O
Grant:
90770
OPP1040463
OPP1040463
OPP1040463
OPP1040463
OPP1040463
OPP1040463
90770
More from this funder
Funding agency for:
Giacomantonio, R
Henrichs, C
Pearson, R
McVean, G
Rockett, K
Miles, A
Jeffery, B
Almagro-Garcia, J
Miotto, O
Cornelius, V
Kwiatkowski, D
Grant:
90770
90770
90770
090532/Z/09/Z
90770
90770
90770
90770
90770
90770
90770
More from this funder
Funding agency for:
Giacomantonio, R
McVean, G
Rockett, K
Miles, A
Jeffery, B
Kwiatkowski, D
Almagro-Garcia, J
Cornelius, V
Miotto, O
Grant:
90770
090532/Z/09/Z
90770
90770
90770
90770
90770
90770
90770
National Institute of Allergy and Infectious Diseases More from this funder
Publisher:
eLife Sciences Publisher's website
Journal:
eLife Journal website
Volume:
5
Article number:
e08714
Publication date:
2016-03-01
Acceptance date:
2015-12-23
DOI:
EISSN:
2050-084X
Source identifiers:
609909
Language:
English
Keywords:
Pubs id:
pubs:609909
UUID:
uuid:4b95f36e-8219-4708-85cf-e2380aa986f4
Local pid:
pubs:609909
Deposit date:
2016-03-15

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