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Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.

Abstract:

CD8⁺ T cells mediate immunity against Plasmodium liver stages. However, the paucity of parasite-specific epitopes of CD8⁺ T cells has limited our current understanding of the mechanisms influencing the generation, maintenance and efficiency of these responses. To identify antigenic epitopes in a stringent murine malaria immunisation model, we performed a systematic profiling of H(2b)-restricted peptides predicted from genome-wide analysis. We describe the identification of Plasmodium berghei ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1003303

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
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Funding agency for:
Hill, AVS
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
9
Issue:
5
Pages:
e1003303
Publication date:
2013-05-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:4b8af258-9f14-40ad-8115-c6d841cafd4d
Source identifiers:
405857
Local pid:
pubs:405857

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