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In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope.

Abstract:

Celiac disease (CD) is an increasingly diagnosed enteropathy (prevalence, 1:200-1:300) that is induced by dietary exposure to wheat gliadins (as well as related proteins in rye and barley) and is strongly associated with HLA-DQ2 (alpha1*0501, beta1*0201), which is present in over 90% of CD patients. Because a variety of gliadin peptides have been identified as epitopes for gliadin-specific T-cell clones and as bioactive sequences in feeding studies and in ex vivo CD intestinal biopsy challeng...

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Publication status:
Published

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Publisher copy:
10.1038/73200

Authors


Anderson, RP More by this author
Godkin, AJ More by this author
Jewell, DP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Nature medicine
Volume:
6
Issue:
3
Pages:
337-342
Publication date:
2000-03-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:4b8987a6-8c4c-4525-8d26-435a225959a0
Source identifiers:
31634
Local pid:
pubs:31634

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