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Inborn and acquired metabolic defects in cancer.

Abstract:

The observation that altered metabolism is the fundamental cause of cancer was made by Otto Warburg nearly a century ago. However, the subsequent identification of oncogenes and tumor suppressor genes has displaced Warburg's theory pointing towards genetic aberrations as the underlining cause of cancer. Nevertheless, in the last decade, cancer-associated mutations have been identified in genes coding for tricarboxylic acid cycle (TCA cycle, also known as Krebs cycle) and closely related enzym...

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Publication status:
Published

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Publisher copy:
10.1007/s00109-011-0728-4

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Journal of molecular medicine (Berlin, Germany)
Volume:
89
Issue:
3
Pages:
213-220
Publication date:
2011-03-01
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
Source identifiers:
149851
Language:
English
Keywords:
Pubs id:
pubs:149851
UUID:
uuid:4b88c976-1af8-474c-a31d-f7ee028554b3
Local pid:
pubs:149851
Deposit date:
2012-12-19

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