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Inborn and acquired metabolic defects in cancer.

Abstract:

The observation that altered metabolism is the fundamental cause of cancer was made by Otto Warburg nearly a century ago. However, the subsequent identification of oncogenes and tumor suppressor genes has displaced Warburg's theory pointing towards genetic aberrations as the underlining cause of cancer. Nevertheless, in the last decade, cancer-associated mutations have been identified in genes coding for tricarboxylic acid cycle (TCA cycle, also known as Krebs cycle) and closely related enzym...

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Publication status:
Published

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Publisher copy:
10.1007/s00109-011-0728-4

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Journal of molecular medicine (Berlin, Germany)
Volume:
89
Issue:
3
Pages:
213-220
Publication date:
2011-03-05
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
URN:
uuid:4b88c976-1af8-474c-a31d-f7ee028554b3
Source identifiers:
149851
Local pid:
pubs:149851

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