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Transcriptional promiscuity of the human alpha-globin gene.

Abstract:

The human alpha-globin gene displays the unusual property of transcriptional promiscuity: that is, it functions in the absence of an enhancer when transfected into nonerythroid cell lines. It is also unusual in that its promoter region lies in a hypomethylated HpaII tiny fragment (HTF) island containing multiple copies of the consensus sequence for the SP1-binding site. We have investigated whether there is a relationship between these two observations. First, we investigated the mouse alpha-...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular and cellular biology
Volume:
9
Issue:
1
Pages:
241-251
Publication date:
1989-01-01
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
30683

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