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Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure

Abstract:

The PfEMP1 family of Plasmodium falciparum antigens play a key role in pathogenesis of severe malaria through their insertion into the surface of parasite infected erythrocytes, and adhesion to host cells. Previous studies have suggested that parasites expressing PfEMP1 subclasses group A and DC8, associated with severe malaria, may have a growth advantage in immunologically naïve individuals. However, this idea has not been tested in longitudinal studies.Here we assessed expression of the va...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12879-017-2686-0

Authors


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Department:
Oxford, MSD, NDM, Jenner Institute
Muthui, MK More by this author
Kivisi, CA More by this author
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Grant:
SP 2011.41304.062 to Bernard Ogutu, Kevin Marsh, Stephen L. Hoffman, Susanne H. Hodgson
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Grant:
103956 to AA, 097940 to SHH, 106917 to SJD, 084535 to PCB and KM
Publisher:
BioMed Central Publisher's website
Journal:
BMC Infectious Diseases Journal website
Volume:
17
Issue:
1
Pages:
Article: 585
Publication date:
2017-08-23
DOI:
ISSN:
1471-2334
Pubs id:
pubs:724974
URN:
uri:4b678149-702f-4f99-8b11-8b68d339a01a
UUID:
uuid:4b678149-702f-4f99-8b11-8b68d339a01a
Local pid:
pubs:724974
Paper number:
1

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