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Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure

Abstract:

The PfEMP1 family of Plasmodium falciparum antigens play a key role in pathogenesis of severe malaria through their insertion into the surface of parasite infected erythrocytes, and adhesion to host cells. Previous studies have suggested that parasites expressing PfEMP1 subclasses group A and DC8, associated with severe malaria, may have a growth advantage in immunologically naïve individuals. However, this idea has not been tested in longitudinal studies.Here we assessed expression of the va...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12879-017-2686-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Grant:
103956toAA,097940toSHH,106917toSJD,084535toPCB
KM
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Grant:
SP 2011.41304.062 to Bernard Ogutu, Kevin Marsh, Stephen L. Hoffman, Susanne H. Hodgson
Publisher:
BioMed Central Publisher's website
Journal:
BMC Infectious Diseases Journal website
Volume:
17
Issue:
1
Article number:
585
Publication date:
2017-08-23
Acceptance date:
2017-08-15
DOI:
ISSN:
1471-2334
Pmid:
28835215
Source identifiers:
724974
Language:
English
Keywords:
Pubs id:
pubs:724974
UUID:
uuid:4b678149-702f-4f99-8b11-8b68d339a01a
Local pid:
pubs:724974
Deposit date:
2017-09-08

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