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Journal article

Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis.

Abstract:

Multiple sclerosis (MS) susceptibility is characterized by maternal parent-of-origin effects and increased female penetrance. In 7796 individuals from 1797 MS families (affected individuals n = 2954), we further implicate epigenetic modifications within major histocompatibility complex (MHC) class II haplotypes as mediating these phenomena. Affected individuals with the main MS-associated allele HLA-DRB1*15 had a higher female-to-male ratio versus those lacking it (P = 0.00023). Distorted tra...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddq282

Authors


Herrera, BM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Handunetthi, L More by this author
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Journal:
Human molecular genetics
Volume:
19
Issue:
18
Pages:
3679-3689
Publication date:
2010-09-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:4b61a67c-d557-4a1d-9654-a570e9b37aca
Source identifiers:
65287
Local pid:
pubs:65287

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