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ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells

Abstract:

RAS mutations occur frequently in human cancer and activated RAS signalling contributes to tumour development and progression. Apart from its oncogenic effects on cell growth, active RAS has tumour-suppressive functions via its ability to induce cellular senescence and apoptosis. RAS is known to induce p53-dependent cell cycle arrest, yet its effect on p53-dependent apoptosis remains unclear. We report here that apoptosis-stimulating protein of p53 (ASPP) 1 and 2, two activators of p53, prefe...

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Publisher copy:
10.1038/cdd.2013.3

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Journal:
Cell Death and Differentiation
Volume:
20
Issue:
4
Pages:
525-534
Publication date:
2013-04-05
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
URN:
uuid:4b57d800-3d3a-4800-969e-b77f48eccfe2
Source identifiers:
394107
Local pid:
pubs:394107
Language:
English
Keywords:

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