NFAT-dependent gene expression is essential for the development and function of the nervous, immune, and cardiovascular systems and kidney, bone, and skeletal muscle. Most NFAT protein resides in the cytoplasm because of extensive phosphorylation, which masks a nuclear localization sequence. Dephosphorylation by the Ca(2+)-calmodulin-activated protein phosphatase calcineurin triggers NFAT migration into the nucleus. In some cell types, NFAT can be activated by Ca(2+) nanodomains near open sto...Expand abstract
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articletitle: Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1
journaltitle: Current Biology
copyright: Copyright © 2014 The Authors. Published by Elsevier Ltd.
Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.
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