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A 31P-NMR study of muscle exercise metabolism in mdx mice: evidence for abnormal pH regulation.

Abstract:

We have studied exercise metabolism in vivo in the mdx mouse model of Duchenne muscular dystrophy with 31P-nuclear magnetic resonance spectroscopy. Intracellular pH, ratios of phosphocreatine (PCr) to ATP and PCr to inorganic phosphate (P(i)) expressed as PCr/ATP and PCr/(PCr+P(i)) as well as tension generated at the Achilles tendon were measured during sciatic nerve stimulation. Tension was similar between the mdx and control strain C57Bl/10ScSn at 10 Hz stimulation but slightly higher than ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
J Neurol Sci
Volume:
113
Issue:
1
Pages:
108-113
Publication date:
1992-11-05
DOI:
ISSN:
0022-510X
URN:
uuid:4b37276d-f9fa-4520-b96e-cc5a2f9da376
Source identifiers:
376242
Local pid:
pubs:376242

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