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Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons.

Abstract:

Cerebellar Purkinje neurons accumulated propidium iodide, granular blue, and horseradish peroxidase conjugated to wheat germ agglutinin but not unconjugated horseradish peroxidase, bisbenzimide, or Evans blue when these compounds were infused into the lateral cerebral ventricles of awake, unrestrained rats. Accumulation of propidium iodide by Purkinje neurons of the vermis was associated with a reproducible behavioral abnormality characterized by truncal tremor, ataxia, and nystagmus. Both th...

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Publication status:
Published

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Publisher copy:
10.1126/science.2580350

Authors


Borges, LF More by this author
Elliott, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Iversen, LL More by this author
Journal:
Science (New York, N.Y.)
Volume:
228
Issue:
4697
Pages:
346-348
Publication date:
1985-04-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:4b36a3d3-e5ae-4aef-af7e-b7139d1d2033
Source identifiers:
22899
Local pid:
pubs:22899

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