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Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians

Abstract:

Background: Trachoma, a chronic keratoconjunctivitis caused by Chlamydia trachomatis, is the world's commonest infectious cause of blindness. Blindness is due to progressive scarring of the conjunctiva (trachomatous scarring) leading to in-turning of eyelashes (trichiasis) and corneal opacification. We evaluated the contribution of genetic variation across the chemokine and cytokine clusters in chromosomes 4q and 5q31 respectively to risk of scarring tr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2350-10-138

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Medical Genetics Journal website
Volume:
10
Pages:
Article: 138
Publication date:
2009-12-16
Acceptance date:
2009-12-16
DOI:
EISSN:
1471-2350
URN:
uuid:4b2c1250-2aa8-4129-b325-753a570de541
Source identifiers:
190725
Local pid:
pubs:190725

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