Journal article
Synthetic access to hydrophilic tetramate derivatives of cysteine
- Abstract:
- The synthesis, structural, and antibacterial evaluation of bicyclic tetramate derivatives of cysteine rendered hydrophilic with pendant heterocyclic substituents is reported; effective synthetic protocols and antibacterial activity for a small library of polar derivatives were found, and direct evidence for strong metal chelation in these systems was obtained. A computational study has developed a detailed understanding of the controlling factors of the key Dieckmann cyclization step.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, 1.2MB, Terms of use)
-
- Publisher copy:
- 10.1021/acs.joc.0c01636
Authors
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Organic Chemistry More from this journal
- Volume:
- 85
- Issue:
- 19
- Pages:
- 12393-12407
- Place of publication:
- United States
- Publication date:
- 2020-09-03
- Acceptance date:
- 2020-08-16
- DOI:
- EISSN:
-
1520-6904
- ISSN:
-
1520-6904
- Pmid:
-
32880449
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
1133662
- Local pid:
-
pubs:1133662
- Deposit date:
-
2020-12-03
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2020
- Rights statement:
- © 2020 American Chemical Society
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from ACS Publications at: https://doi.org/10.1021/acs.joc.0c01636
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record