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Gene regulatory networks: a coarse-grained, equation-free approach to multiscale computation.

Abstract:

We present computer-assisted methods for analyzing stochastic models of gene regulatory networks. The main idea that underlies this equation-free analysis is the design and execution of appropriately initialized short bursts of stochastic simulations; the results of these are processed to estimate coarse-grained quantities of interest, such as mesoscopic transport coefficients. In particular, using a simple model of a genetic toggle switch, we illustrate the computation of an effective free e...

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Publication status:
Published

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Publisher copy:
10.1063/1.2149854

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Kevrekidis, IG More by this author
Adalsteinsson, D More by this author
Elston, TC More by this author
Journal:
The Journal of chemical physics
Volume:
124
Issue:
8
Pages:
084106
Publication date:
2006-02-05
DOI:
EISSN:
1089-7690
ISSN:
0021-9606
URN:
uuid:4b243aa8-321f-4b20-899e-f6b712343ae3
Source identifiers:
29133
Local pid:
pubs:29133

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