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Dynactin suppresses the retrograde movement of apically localized mRNA in Drosophila blastoderm embryos.

Abstract:

Motor dependent transport of mRNA is a key mechanism in axis specification during development. Apical transport and anchoring of wingless and pair-rule transcripts in the Drosophila syncytial blastoderm embryo is mediated by cytoplasmic Dynein, the major minus end directed microtubule dependent molecular motor. Here, we show that, despite apical transport of mRNA being highly directional, mRNA particles often pause and move backward toward the plus ends of microtubules. We suggest that this r...

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Publication status:
Published

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Publisher copy:
10.1261/rna.509007

Authors


Hamilton, RS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
RNA (New York, N.Y.)
Volume:
13
Issue:
11
Pages:
1860-1867
Publication date:
2007-11-05
DOI:
EISSN:
1469-9001
ISSN:
1355-8382
URN:
uuid:4b21e498-b3f0-4c26-a09b-6f764a49115c
Source identifiers:
100710
Local pid:
pubs:100710

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