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OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.

Abstract:

Conjugation of Met1-linked polyubiquitin (Met1-Ub) by the linear ubiquitin chain assembly complex (LUBAC) is an important regulatory modification in innate immune signaling. So far, only few Met1-Ub substrates have been described, and the regulatory mechanisms have remained elusive. We recently identified that the ovarian tumor (OTU) family deubiquitinase OTULIN specifically disassembles Met1-Ub. Here, we report that OTULIN is critical for limiting Met1-Ub accumulation after nucleotide-oligom...

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Authors


Damgaard, RB More by this author
Wagner, SA More by this author
Keusekotten, K More by this author
Fritsch, M More by this author
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Journal:
Molecular cell
Volume:
50
Issue:
6
Pages:
818-830
Publication date:
2013-06-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:4b1d4ab3-a5b2-4e57-8ab5-f1aed81581a1
Source identifiers:
423553
Local pid:
pubs:423553

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