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The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.

Abstract:

Isopenicillin N synthase (IPNS) converts the linear tripeptide δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV) into bicyclic isopenicillin N (IPN) in the central step in the biosynthesis of penicillin and cephalosporin antibiotics. Solution-phase incubation experiments have shown that IPNS turns over analogues with a diverse range of side chains in the third (valinyl) position of the substrate, but copes less well with changes in the second (cysteinyl) residue. IPNS thus converts the homologa...

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Publication status:
Published

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Publisher copy:
10.1002/cbic.201200728

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Chembiochem : a European journal of chemical biology
Volume:
14
Issue:
5
Pages:
599-606
Publication date:
2013-03-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:4b1a332c-f9cc-496c-9084-8f502716d631
Source identifiers:
387754
Local pid:
pubs:387754

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