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GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal.

Abstract:

Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1), wild-type controls, mice with cytotoxic hippocampal lesions, and controls that had undergone sham surgery. In agreement with previous studies using tasks such as the water maze, GluR-A(-/-) mice were unimpaired during acquisition of the spatial discrimination task, whereas performance in the hippocampa...

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Publication status:
Published

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Publisher copy:
10.1037/0735-7044.117.4.866

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Behavioral neuroscience
Volume:
117
Issue:
4
Pages:
866-870
Publication date:
2003-08-05
DOI:
EISSN:
1939-0084
ISSN:
0735-7044
URN:
uuid:4b112ea7-3d8c-426a-a744-bb1a2b7f8fa7
Source identifiers:
23177
Local pid:
pubs:23177

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