- Abstract:
-
Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1), wild-type controls, mice with cytotoxic hippocampal lesions, and controls that had undergone sham surgery. In agreement with previous studies using tasks such as the water maze, GluR-A(-/-) mice were unimpaired during acquisition of the spatial discrimination task, whereas performance in the hippocampa...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1037/0735-7044.117.4.866
-
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- Journal:
- Behavioral neuroscience
- Volume:
- 117
- Issue:
- 4
- Pages:
- 866-870
- Publication date:
- 2003-08-05
- DOI:
- EISSN:
-
1939-0084
- ISSN:
-
0735-7044
- URN:
-
uuid:4b112ea7-3d8c-426a-a744-bb1a2b7f8fa7
- Source identifiers:
-
23177
- Local pid:
- pubs:23177
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal.
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