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Modulation of TASK-like background potassium channels in rat arterial chemoreceptor cells by intracellular ATP and other nucleotides.

Abstract:

The carotid body's physiological role is to sense arterial oxygen, CO(2) and pH. It is however, also powerfully excited by inhibitors of oxidative phosphorylation. This latter observation is the cornerstone of the mitochondrial hypothesis which proposes that oxygen is sensed through changes in energy metabolism. All of these stimuli act in a similar manner, i.e. by inhibiting a background TASK-like potassium channel (K(B)) they induce membrane depolarization and thus neurosecretion. In this s...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Journal of physiology
Volume:
583
Issue:
Pt 2
Pages:
521-536
Publication date:
2007-09-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:4b0ced62-2431-4068-bf02-ca44d36a7b58
Source identifiers:
312267
Local pid:
pubs:312267

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