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Journal article

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation

Abstract:

Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs), FLT3 internal tandem duplications (FLT3 ITDs) have recently been suggested to intrinsically suppress HSCs. Herein, single-cell interrogation found Flt3 mRNA expression to be absent in the large majority of phenotypic HSCs, with a strong negative correlation between Flt3 and HSC-associated gene expression. Flt3-ITD knock-in mice showed redu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20161418

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Funding agency for:
Mead, A
Grant:
Senior Clinical Fellowship (MR/L006340/1
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Funding agency for:
Mead, A
Grant:
Senior Clinical Fellowship (MR/L006340/1
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Funding agency for:
Chowdhury, O
Grant:
Clinical fellowship
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Funding agency for:
Jacobsen, S
Grant:
G0801073
MC_ UU_12009/5
More from this funder
Funding agency for:
Jacobsen, S
Grant:
G0801073
MC_ UU_12009/5
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
214
Issue:
7
Pages:
2005-2021
Publication date:
2017-06-21
Acceptance date:
2017-05-08
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
701852
Language:
English
Pubs id:
pubs:701852
UUID:
uuid:4ae203b2-8320-4c9d-8bb8-33503112494b
Local pid:
pubs:701852
Deposit date:
2017-06-26

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