Long-chain polyunsaturated fatty acids and the regulation of bone metabolism.

Journal article

The role of prostaglandin E2 (PGE2) in the regulation of bone remodeling is well established. There is increasing evidence that various long-chain polyunsaturated fatty acids (LCPUFAs), as well as nonprostanoid LCPUFA metabolites, also have critical roles in regulating bone metabolism and may have therapeutic potential in the management of postmenopausal osteoporosis. Although only the 18-carbon precursors for the n-3 and n-6 LCPUFAs are deemed "dietary essential," the ability of the body to ...

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Authors: Poulsen, R; Moughan, P; Kruger, M

• Publication status: Published
• Journal: Experimental biology and medicine (Maywood, N.J.)
• Volume: 232
• Issue: 10
• Pages: 1275-1288
• Publication date: 2007-11-01
• DOI: 10.3181/0704-mr-100
• EISSN: 1535-3699
• ISSN: 1535-3702
• Language: English
• Keywords: Bone and Bones; Homeostasis; Middle Aged; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Aged; Humans; Adult; Epoxide Hydrolases; Oxidation-Reduction; Lipoxygenase; Animals; Female; Fatty Acids, Unsaturated; Osteoporosis, Postmenopausal; Models, Animal