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N.m.r. determination of the solution conformation and dynamics of the A.G mismatch in the d(CGCAAATTGGCG)2 dodecamer.

Abstract:

A.G base-paired mismatches that occur during replication are among the most difficult to detect by repair enzymes. Such purine.purine mispairs can exist in two conformations, one of which is stabilized by protons [Gao and Patel (1988) J. Am. Chem. Soc. 110, 5178-5182]. We have undertaken a 1H-n.m.r. and 31P-n.m.r. study of the mismatched dodecamer d(CGCAAATTGGCG)2 as a function of both temperature and pH to determine the conformational features of the A.G mismatch. At pH greater than 7 the mi...

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Publication status:
Published

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Authors


Jenkins, TC More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
The Biochemical journal
Volume:
279 ( Pt 1)
Pages:
269-281
Publication date:
1991-10-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:4adfaaec-8675-4fb1-9474-5ba53dfe9f65
Source identifiers:
400418
Local pid:
pubs:400418

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