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Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters

Abstract:

A major challenge in drug development is the optimization of intestinal absorption and cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack solute carrier (SLC) transporters for active transport into the body. The proton-coupled oligopeptide transporters, PepT1 and PepT2, have been successfully targeted using this approach. Peptide transporters display a remarkable capacity to recognize a diverse library of di- and tripeptides, making them extremely promi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1813715116

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
ORCID:
0000-0003-4320-1243
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Christ Church
Role:
Author
ORCID:
0000-0001-7432-2270
More from this funder
Funding agency for:
Newstead, S
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
3
Pages:
804-809
Publication date:
2019-01-02
Acceptance date:
2018-12-06
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:936913
URN:
uri:4adbbac1-39ef-4325-9341-b5f3c590cf34
UUID:
uuid:4adbbac1-39ef-4325-9341-b5f3c590cf34
Local pid:
pubs:936913

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