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Heat shock protein-based therapy for sphingolipidoses

Abstract:
Lysosomal diseases often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited and have no or only modest efficacy against neurological manifestations of disease. We recently demonstrated that recombinant HSP70 improves the binding of several sphingolipid-degrading enzymes to their essential co-factor, bis(monoacylglycero)phosphate, in vitro
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.ymgme.2016.11.178

Authors


Kirkegaard, T More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Petersen, N More by this author
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Publisher:
Elsevier Publisher's website
Publication date:
2017-02-05
DOI:
ISSN:
1096-7192
Pubs id:
pubs:719204
URN:
uri:4ac3bf8e-231c-4e41-9f8c-90172d2dcde0
UUID:
uuid:4ac3bf8e-231c-4e41-9f8c-90172d2dcde0
Local pid:
pubs:719204

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