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Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).

Abstract:

CD2, also known as LFA-2, T11, and the E rosette receptor, is a T lymphocyte surface protein functionally important in adhesion to target cells and T cell triggering. LFA-3 is a widely distributed cell surface protein that functions in adhesion on target cells. We find that LFA-3 is expressed on human E, and that CD2 is a receptor for LFA-3 that mediates T cell adhesion to human E. Pretreatment of T lymphocytes with CD2 mAb or of E with LFA-3 mAb inhibits rosetting. Purified CD2 molecules bin...

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Publisher copy:
10.1084/jem.165.3.664

Authors


Plunkett, ML More by this author
Sanders, ME More by this author
Selvaraj, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Springer, TA More by this author
Journal:
The Journal of experimental medicine
Volume:
165
Issue:
3
Pages:
664-676
Publication date:
1987-03-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:4abc0d73-27ca-48ed-874c-24895b52fe95
Source identifiers:
482692
Local pid:
pubs:482692

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