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Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury

Abstract:

Plasmodium knowlesi occurs throughout Southeast Asia, and is the most common cause of human malaria in Malaysia. Severe disease in humans is characterised by high parasite biomass, reduced red blood cell deformability, endothelial activation and microvascular dysfunction. However, the roles of intravascular haemolysis and nitric oxide (NO)-dependent endothelial dysfunction, important features of severe falciparum malaria, have not been evaluated, nor their role in acute kidney injury (AKI). I...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41426-018-0105-2

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Role:
Author
ORCID:
0000-0003-1066-7960
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Role:
Author
ORCID:
0000-0002-3643-7605
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Publisher:
Springer Nature Publisher's website
Journal:
Emerging Microbes and Infections Journal website
Volume:
7
Publication date:
2018-06-06
Acceptance date:
2018-05-08
DOI:
EISSN:
2222-1751
Pubs id:
pubs:857572
URN:
uri:4ab95a16-9d8d-4526-8148-36252c46a851
UUID:
uuid:4ab95a16-9d8d-4526-8148-36252c46a851
Local pid:
pubs:857572
Language:
English

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