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Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection.

Abstract:

After virus infection, cytotoxic T lymphocytes (CTLs) divide rapidly to eradicate the pathogen and prevent the establishment of persistence. The magnitude of an antiviral CTL response is thought to be controlled by the initiation of a cell cycle program within lymphoid tissues. However, it is presently not known whether this division program proceeds during migration or is influenced locally at sites of viral infection. We demonstrate that antiviral CTLs remain in cell cycle while transiting ...

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Publisher copy:
10.1084/jem.20101295

Authors


Stewart-Hutchinson, P More by this author
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Journal:
The Journal of experimental medicine
Volume:
208
Issue:
4
Pages:
747-759
Publication date:
2011-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:4aad11ee-57d7-4ed3-9e53-108f522f1d21
Source identifiers:
426271
Local pid:
pubs:426271

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