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A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease.

Abstract:

Single-nucleotide polymorphisms (SNPs) within the tumour necrosis factor alpha (TNF-alpha) gene on chromosome 6p21.3 have been associated with many autoimmune diseases; however, results have been conflicting and accurate allele frequencies have never been established in a UK Caucasian population. The aim of this study was to assess the frequency of 22 known TNF-alpha SNPs in a UK Caucasian control population and investigate association of all polymorphisms with >5% minor allele frequency i...

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Publisher copy:
10.1038/sj.gene.6364066

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Heward, JM More by this author
Howson, JM More by this author
Nithiyananthan, R More by this author
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Journal:
Genes and immunity
Volume:
5
Issue:
4
Pages:
267-273
Publication date:
2004-06-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:4aa1bdf1-0c1d-47d4-b734-d113cf673cbe
Source identifiers:
176345
Local pid:
pubs:176345

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