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Journal article

Genotype-specific MRD interpretation improves stratification in paediatric acute lymphoblastic leukaemia

Abstract:
Purpose Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia. Current risk algorithms dichotomize MRD data and do not assimilate genetics when assigning MRD risk, which reduces predictive accuracy. The aim of our study was to exploit the full power of MRD by examining it as a continuous variable and to integrate it with genetics. Patients and Methods We used a population-based cohort ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1200/JCO.2017.74.0449

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Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
36
Issue:
1
Pages:
34-43
Publication date:
2017-11-13
Acceptance date:
2017-09-26
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
Pubs id:
pubs:745909
URN:
uri:4a972813-f7b6-4f4f-8f55-5bc3c8c7dabd
UUID:
uuid:4a972813-f7b6-4f4f-8f55-5bc3c8c7dabd
Local pid:
pubs:745909
Paper number:
1

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