A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging.

Journal article

Molecules labelled with the unnatural isotope fluorine-18 are used for positron emission tomography. Currently, this molecular imaging technology is not exploited at its full potential because many (18)F-labelled probes are inaccessible or notoriously difficult to produce. Typical challenges associated with (18)F radiochemistry are the short half-life of (18)F (<2 h), the use of sub-stoichiometric amounts of (18)F, relative to the precursor and other reagents, as well as the limited availa...

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Authors: Huiban, M; Tredwell, M; Mizuta, S; Wan, Z; Zhang, X

• Publication status: Published
• Journal: Nature chemistry
• Volume: 5
• Issue: 11
• Pages: 941-944
• Publication date: 2013-11-01
• DOI: 10.1038/nchem.1756
• EISSN: 1755-4349
• ISSN: 1755-4330
• Language: English
• Keywords: Benzene Derivatives; Isotope Labeling; Molecular Structure; Hydrocarbons, Fluorinated; Flutamide; Positron-Emission Tomography; Fluorine Radioisotopes; Molecular Imaging; Methylation; Magnetic Resonance Spectroscopy; Iodobenzenes; Fluoxetine