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A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging.

Abstract:

Molecules labelled with the unnatural isotope fluorine-18 are used for positron emission tomography. Currently, this molecular imaging technology is not exploited at its full potential because many (18)F-labelled probes are inaccessible or notoriously difficult to produce. Typical challenges associated with (18)F radiochemistry are the short half-life of (18)F (<2 h), the use of sub-stoichiometric amounts of (18)F, relative to the precursor and other reagents, as well as the limited availa...

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Publication status:
Published

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Publisher copy:
10.1038/nchem.1756

Authors


Tredwell, M More by this author
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Journal:
Nature chemistry
Volume:
5
Issue:
11
Pages:
941-944
Publication date:
2013-11-05
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
URN:
uuid:4a8c2777-4e79-4991-b595-ae3dda7fe783
Source identifiers:
427686
Local pid:
pubs:427686

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