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Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131.

Abstract:

OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01130-16

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Peirano, G More by this author
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Department of Health More from this funder
Calgary Laboratory Services More from this funder
Public Health England More from this funder
National Institute for Health Research More from this funder
Publisher:
American Association for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
60
Issue:
11
Pages:
6948-6951
Publication date:
2016-09-05
Acceptance date:
2016-08-23
DOI:
ISSN:
0066-4804 and 1098-6596
Pubs id:
pubs:645803
URN:
uri:4a86d203-16c1-48e1-91f0-f9bc229b5733
UUID:
uuid:4a86d203-16c1-48e1-91f0-f9bc229b5733
Local pid:
pubs:645803

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