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Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131.

Abstract:

OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01130-16

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
Publisher:
American Association for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
60
Issue:
11
Pages:
6948-6951
Publication date:
2016-09-01
Acceptance date:
2016-08-23
DOI:
ISSN:
1098-6596 and 0066-4804
Pmid:
27600043
Language:
English
Keywords:
Pubs id:
pubs:645803
UUID:
uuid:4a86d203-16c1-48e1-91f0-f9bc229b5733
Local pid:
pubs:645803
Source identifiers:
645803
Deposit date:
2017-11-14

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