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Journal article

Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity.

Abstract:

AIMS: Caveolin-1 (Cav-1) interacts with large conductance Ca(2+)-activated potassium channels (BKCa) and likely exerts a negative regulatory effect on the channel activity. We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity. METHODS AND RESULTS: In isolated, pressurized (80 mmHg) gracilis muscle arterioles (approximately 100 microm)...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvq088

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Journal:
Cardiovascular research
Volume:
87
Issue:
4
Pages:
732-739
Publication date:
2010-09-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:4a6de80e-b9d5-4c98-9da7-962760a60d28
Source identifiers:
164450
Local pid:
pubs:164450

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