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Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.

Abstract:

BACKGROUND: Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy. MATERIALS/METHODS: To evaluate genetic determinants of %fPSA, we conducted a genome-wide association study of serum %fPSA by genotyping 642,584 single nucleotide polymorphisms (SNPs) in 31...

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Publisher copy:
10.1593/neo.121620

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
Neoplasia (New York, N.Y.)
Volume:
15
Issue:
1
Pages:
95-101
Publication date:
2013-01-05
DOI:
EISSN:
1476-5586
ISSN:
1522-8002
URN:
uuid:4a67f911-18c1-4a8d-8a5b-dd54b1f478aa
Source identifiers:
375934
Local pid:
pubs:375934

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