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11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

Abstract:

Objective In rheumatoid arthritis, the enzyme 11 beta-hydroxysteroid dehydrogenase type 1(11β-HSD1) is highly expressed at sites of inflammation, where it converts inactive glucocorticoids (GC) to their active counterparts. In conditions of GC excess it has been shown to be a critical regulator of muscle wasting and bone loss. Here we examine the contribution of 11β-HSD1 to the pathology of persistent chronic inflammatory disease.

Methods To determi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.jaut.2018.05.010

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ORCID:
0000-0001-6938-6739
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ORCID:
0000-0002-9487-0511
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ORCID:
0000-0001-8384-8215
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Volume:
92
Pages:
104-113
Publication date:
2018-06-08
Acceptance date:
2018-05-29
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Pubs id:
pubs:895008
URN:
uri:4a4f9eee-29d7-43ac-bf1e-c516da321835
UUID:
uuid:4a4f9eee-29d7-43ac-bf1e-c516da321835
Local pid:
pubs:895008
Language:
English

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