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Journal article

In the ring with polycystic kidney disease--avoiding the knockout punch.

Abstract:

Autosomal dominant polycystic kidney disease (PKD) is an inherited disease that results from mutations in either polycystin (PKD1) or polycystin 2 (PKD2), both of which are large, complex, and multifunctional proteins whose loss results in the development of numerous fluid-filled cysts and fibrosis that compromise renal function. A number of spontaneous and engineered mouse models of PKD have provided some understanding of many aspects of cyst development, modifier genes, and mechanistic path...

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Publication status:
Published

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Publisher copy:
10.1002/path.2782

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
The Journal of pathology
Volume:
223
Issue:
1
Pages:
1-3
Publication date:
2011-01-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:4a457b24-1817-4ed4-9d19-3cd8c9c954d4
Source identifiers:
95279
Local pid:
pubs:95279

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