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Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare.

Abstract:

We have studied the effects of groups II and III metabotropic glutamate receptor (mGluR) activation on excitatory responses recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare (SLM). Excitatory postsynaptic currents (EPSCs) evoked by stimulation of the perforant pathway were reduced either by the group II mGluR agonist LY354740 (50-100 nM, 49.1+/-5.7% of control) or by the group III mGluR agonist l-2-amino-4-phosphonobutyric acid (l-AP4) (50 microM, 36.8+/-4.4% of contr...

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Publication status:
Published

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Authors


Karayannis, T More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Neuropharmacology
Volume:
49 Suppl 1
Issue:
SUPPL.
Pages:
45-56
Publication date:
2005
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:4a30cf92-d94a-4fa4-a25c-3a200bb24425
Source identifiers:
329219
Local pid:
pubs:329219

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