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Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.

Abstract:

Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for these diseases have identified a number of individual genetic variants contributing to the risk of those diseases. However, the effect size for most variants is small and collectively the known variants explain only a small proportion of the estimated heritability. We used ...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/dds491

Authors


Nyholt, DR More by this author
Goddard, ME More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Human molecular genetics
Volume:
22
Issue:
4
Pages:
832-841
Publication date:
2013-02-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:4a2bc177-9a1c-499a-b83d-dff4d01528f0
Source identifiers:
365493
Local pid:
pubs:365493

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