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Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.

Abstract:

Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of pyruvate to lactate, having a principal position in the anaerobic cellular metabolism. Induction of LDH-5 occurs during hypoxia and LDH-5 transcription is directly regulated by the hypoxia-inducible factor 1 (HIF1). Serum LDH levels have been correlated with poor prognosis and resistance to chemotherapy and radiotherapy in various neoplastic diseases. The expression, however, of LDH in tumours has never been investigat...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6601205

Authors


Koukourakis, MI More by this author
Giatromanolaki, A More by this author
Sivridis, E More by this author
Bougioukas, G More by this author
Didilis, V More by this author
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Journal:
British journal of cancer
Volume:
89
Issue:
5
Pages:
877-885
Publication date:
2003-09-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:4a26dd7b-12c3-4968-b452-cdb01199014c
Source identifiers:
119292
Local pid:
pubs:119292

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