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The role of MAPT sequence variation in mechanisms of disease susceptibility.

Abstract:

The microtubule-associated protein tau (MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement disorders. The genomic architecture in the region spanning the MAPT locus contains a ~1.8 Mb block of linkage disequilibrium characterized by two major haplotypes: H1 and H2. Recent studies have established strong genetic association betwee...

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Publication status:
Published

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Publisher copy:
10.1042/bst20120063

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Biochemical Society transactions
Volume:
40
Issue:
4
Pages:
687-692
Publication date:
2012-08-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:4a1c0fde-ad76-4d49-8853-cc1d54b2d3b8
Source identifiers:
344195
Local pid:
pubs:344195

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