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Thermodynamics of HMGB1 interaction with duplex DNA.

Abstract:

The high mobility group protein HMGB1 is a small, highly abundant protein that binds to DNA in a non-sequence-specific manner. HMGB1 consists of 2 DNA binding domains, the HMG boxes A and B, followed by a short basic region and a continuous stretch of 30 glutamate or aspartate residues. Isothermal titration calorimetry was used to characterize the binding of HMGB1 to the double-stranded model DNAs poly(dAdT).(dTdA) and poly(dGdC).(dCdG). To elucidate the contribution of the different structur...

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Publication status:
Published

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Publisher copy:
10.1021/bi0100900

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Biochemistry
Volume:
40
Issue:
34
Pages:
10254-10261
Publication date:
2001-08-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:4a1b0ad3-e137-4000-8182-5a5a47d30edf
Source identifiers:
374158
Local pid:
pubs:374158

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