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Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Abstract:

Decreased autophagy contributes to malignancies; however, it is unclear how autophagy has an impact on tumor growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the hematopoietic stem and progenitor cells (HSPC) where transformation occurs is well characterized and (iii) loss of the key autophagy gene Atg7 in HSPCs leads to a lethal pre-leukemic phenotype in mice. Here we demonstrate that loss of Atg5 results ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/cddiscovery.2015.8

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
Watson, AS More by this author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Cell Death Discovery Journal website
Volume:
1
Pages:
Article: 15008
Publication date:
2015
DOI:
EISSN:
2058-7716
URN:
uuid:4a0d8f95-c021-4e9c-94dd-ecafe90d87c3
Source identifiers:
535534
Local pid:
pubs:535534

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