Journal article icon

Journal article

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Abstract:

Decreased autophagy contributes to malignancies; however, it is unclear how autophagy has an impact on tumor growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the hematopoietic stem and progenitor cells (HSPC) where transformation occurs is well characterized and (iii) loss of the key autophagy gene Atg7 in HSPCs leads to a lethal pre-leukemic phenotype in mice. Here we demonstrate that loss of Atg5 results ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/cddiscovery.2015.8

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Cell Death Discovery Journal website
Volume:
1
Article number:
15008
Publication date:
2015-01-01
DOI:
EISSN:
2058-7716
Source identifiers:
535534
Pubs id:
pubs:535534
UUID:
uuid:4a0d8f95-c021-4e9c-94dd-ecafe90d87c3
Local pid:
pubs:535534
Deposit date:
2015-08-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP