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Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways.

Abstract:

Tumor necrosis factor alpha (TNFalpha) is a cytokine implicated in the pathogenesis of numerous chronic and acute inflammatory conditions. In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. The intradermal injection of recombinant human TNFalpha induced a slowly developing, dose-dependent...

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Publication status:
Published

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Journal:
Blood
Volume:
90
Issue:
10
Pages:
4144-4152
Publication date:
1997-11-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:4a03892e-6d7e-43be-83f5-a501597ae0f8
Source identifiers:
481603
Local pid:
pubs:481603

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