Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways.

Sanz, MJ; Hartnell, A; Chisholm, P; Williams, C; Davies, D; Weg, VB; Feldmann, M; Bolanowski, MA; Lobb, RR; Nourshargh, S

Abstract:

Tumor necrosis factor alpha (TNFalpha) is a cytokine implicated in the pathogenesis of numerous chronic and acute inflammatory conditions. In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. The intradermal injection of recombinant human TNFalpha induced a slowly developing, dose-dependent...

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APA Style

Sanz, M. J., Hartnell, A., Chisholm, P., Williams, C., Davies, D., Weg, V. B., Feldmann, M., Bolanowski, M. A., Lobb, R. R., & Nourshargh, S. (1997). Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways. Blood, 90(10), 4144–4152.

MLA Style

Sanz, M. J., et al. “Tumor Necrosis Factor Alpha-Induced Eosinophil Accumulation in Rat Skin Is Dependent on alpha4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways.” Blood, vol. 90, no. 10, 1997, pp. 4144–52.

Chicago Style

Sanz, MJ, A Hartnell, P Chisholm, C Williams, D Davies, VB Weg, M Feldmann, MA Bolanowski, RR Lobb, and S Nourshargh. 1997. “Tumor Necrosis Factor Alpha-Induced Eosinophil Accumulation in Rat Skin Is Dependent on alpha4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways.” Blood 90 (10): 4144–52.
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