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Journal article

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.

Abstract:

BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. METHODS AND FINDINGS: We used information from 21 adult cohorts (up to 42,024 participants) with 12 BMI-related SNPs (combined in an allelic score) t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001383

Authors


Vimaleswaran, KS More by this author
Tikkanen, E More by this author
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National Health Executive More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
10
Issue:
2
Pages:
Article: e1001383
Publication date:
2013-01-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:49e67aeb-a156-45d4-b6b9-5c74d544db96
Source identifiers:
389164
Local pid:
pubs:389164

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