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Planarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation.

Abstract:

Planarian adult stem cells (pASCs) or neoblasts represent an ideal system to study the evolution of stem cells and pluripotency as they underpin an unrivaled capacity for regeneration. We wish to understand the control of differentiation and pluripotency in pASCs and to understand how conserved, convergent or divergent these mechanisms are across the Bilateria. Here we show the planarian methyl-CpG Binding Domain 2/3 (mbd2/3) gene is required for pASC differentiation during regeneration and t...

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Publication status:
Published

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Publisher copy:
10.1016/j.ydbio.2013.09.020

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Journal:
Developmental biology
Volume:
384
Issue:
1
Pages:
141-153
Publication date:
2013-12-01
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
Source identifiers:
431155
Language:
English
Keywords:
Pubs id:
pubs:431155
UUID:
uuid:49d663eb-154e-41cc-96f1-2ae6d6f1e088
Local pid:
pubs:431155
Deposit date:
2013-11-16

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