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Notch regulation of tumor angiogenesis.

Abstract:

The growth of new blood vessels (angiogenesis) is critical for tumor growth and progression. The highly conserved Notch signaling pathway is involved in a variety of cell fate decisions and regulates many cellular biological processes, including angiogenesis. Aberrant Notch signaling has also been implicated in tumorigenesis. Notch ligands and receptors are expressed on many different cell types present within the tumor, including tumor cells and the stromal compartment. This article highligh...

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Publication status:
Published

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Publisher copy:
10.2217/fon.11.20

Authors


Bridges, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Biomedical Research Centre, Molecular Medicine
Journal:
Future oncology (London, England)
Volume:
7
Issue:
4
Pages:
569-588
Publication date:
2011-04-05
DOI:
EISSN:
1744-8301
ISSN:
1479-6694
URN:
uuid:49d1340d-9774-4ee3-8d6b-2cca4f6d3657
Source identifiers:
131099
Local pid:
pubs:131099

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