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Monotopic enzymes and lipid bilayers: a comparative study.

Abstract:

Monotopic proteins make up a class of membrane proteins that bind tightly to, but do not span, cell membranes. We examine and compare how two monotopic proteins, monoamine oxidase B (MAO-B) and cyclooxygenase-2 (COX-2), interact with a phospholipid bilayer using molecular dynamics simulations. Both enzymes form between three and seven hydrogen bonds with the bilayer in our simulations with basic side chains accounting for the majority of these interactions. By analyzing lipid order parameters...

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Publication status:
Published

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Publisher copy:
10.1021/bi602455n

Authors


Journal:
Biochemistry
Volume:
46
Issue:
11
Pages:
3108-3115
Publication date:
2007-03-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Source identifiers:
100874
Language:
English
Keywords:
Pubs id:
pubs:100874
UUID:
uuid:49d09b28-4a0c-46e8-81c5-a3491b15e2ce
Local pid:
pubs:100874
Deposit date:
2012-12-19

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