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Monotopic enzymes and lipid bilayers: a comparative study.

Abstract:

Monotopic proteins make up a class of membrane proteins that bind tightly to, but do not span, cell membranes. We examine and compare how two monotopic proteins, monoamine oxidase B (MAO-B) and cyclooxygenase-2 (COX-2), interact with a phospholipid bilayer using molecular dynamics simulations. Both enzymes form between three and seven hydrogen bonds with the bilayer in our simulations with basic side chains accounting for the majority of these interactions. By analyzing lipid order parameters...

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Publication status:
Published

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Publisher copy:
10.1021/bi602455n

Authors


Fowler, PW More by this author
Balali-Mood, K More by this author
Coveney, PV More by this author
Sansom, MS More by this author
Journal:
Biochemistry
Volume:
46
Issue:
11
Pages:
3108-3115
Publication date:
2007-03-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:49d09b28-4a0c-46e8-81c5-a3491b15e2ce
Source identifiers:
100874
Local pid:
pubs:100874

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