A cell topography-based mechanism for ligand discrimination by the T cell receptor
The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In resting T cells, the TCR is largely unphosphorylated due to the dominance of phosphatases over the kinases expressed at the cell surface. However, when agonist peptides are presented to the TCR by maj...Expand abstract
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Copyright © 2019 the Authors. Published by PNAS.
This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
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