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A cell topography-based mechanism for ligand discrimination by the T cell receptor

Abstract:

The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In resting T cells, the TCR is largely unphosphorylated due to the dominance of phosphatases over the kinases expressed at the cell surface. However, when agonist peptides are presented to the TCR by maj...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1817255116

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Grant:
207547/Z/17/Z
098274/12/Z
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
28
Pages:
14002-14010
Publication date:
2019-06-20
Acceptance date:
2019-05-22
DOI:
EISSN:
1091-64909
ISSN:
0027-8424
Pubs id:
pubs:1012648
URN:
uri:49ccb74d-78fd-42cb-8f94-a994c6c22602
UUID:
uuid:49ccb74d-78fd-42cb-8f94-a994c6c22602
Local pid:
pubs:1012648

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